Relevant and even prescient commentary on news, politics and the economy.

The FDA

I am back complaining about the FDA as I have in The Ethics of Clinical Trials and 10 years earlier Clinical Trial Ethics (an aside — I had forgotten the old post and Google reminded me that I have been banging this drum for a decade). Now I have a lot of company, because of […]

Remdesivir IV

This post is not up to the standards of the New England Journal of Medicine Compassionate Use of Remdesivir for Patients with Severe Covid-19 is an important article written and published with amazing speed. The (many) authors (including professional writers) assess the experience of 53 “patients who received remdesivir during the period from January 25, […]

Remdesivir III

I told you so on March 2 2020 The first Covid 19 case diagnosed in New Jersey Around 3 a.m. on March 10, Balani arrived at the hospital. The medicine had come in, and she did not want to wait until the morning to administer it. With Balani in the room, a nurse woke Cai […]

Coronavirus Thoughts

I’m not even going to try to organize this post. I am in self quarantine 6 days after having either the mildest cold I can remember or a mild case of Covid 19 (this means alone in an Air BnB away from my family too). The pattern is the same I have read about countless […]

Rome Update

For 3 days from an abundance of caution, 4 hours a day of online teaching responsibilities and extreme laziness, I have stayed in an apartment usuaally in a bed. Rome is a bit different than was I went into hibernation. There are people walking around without dogs on a leash. Some cars. There was a […]

Hydroxychloroquine update

A clinical trial of hydroxychloroquine with 30 patients (15 treated 15 controls) has been completed in Shanghai. It is the first genuine randomized trial. It reports no evidence that hydroxychloroquine works at all. It is true, that given the principal outcome measure defined in advance, the trial has no power. Not low power, 0 power. […]

Not Just Covid 19, Cancer Too

Chloroquine and Hydroxychloroquine are being tested as components of multi-drug cancer chemotherapy. I have noticed that when I tweet this, people conclude that I am insane. However this is not a tiny literature. \ Repurposing Drugs in Oncology (ReDO)—chloroquine and hydroxychloroquine as anti-cancer agents is a long review article and meta analysis. It cites seven […]