AI is getting a lot of attention these days, and rightfully so. ChatGPT looks to take lots of jobs and to become the plagiarist’s tool of choice. Will AI replace artists, composers and novelists? Time will tell, but to look at what passes for “art” today in the mass consumer market, my money’s on AI. […]

The Yale historian Timothy Snyder first came to my attention in a footnote of an article in The New York Review of Books. The footnote gave a link to a series of 23 online lectures on the history of Ukraine, which I binge-watched over a period of about five days. I also read his books […]

There has been some head-scratching about the recent COVID variant, BA.2.86, which has 34 amino acid changes in the spike protein compared to its closest reference sequence. Commenter rjs asks: “how can one virus suddenly wake up one morning and find it had mutated 30 times overnight? And that all 30 of its mutations were […]

I just finished “War and Punishment: The story of Russian oppression and Ukranian resistance” by Mikhail Zygar. I’ve read several books on Russian and Ukranian history written by historians. Zygar isn’t a historian, and the style of this book is more of a reporter, albeit one describing history. The writing here is vivid, if somewhat […]

These days, microplastics seem to have displaced methane and carbon dioxide as the environmental bogy man. And not that we shouldn’t worry about all pollution sources, but it turns out that, once again, driving is a big problem–not just for global warming but for microplastics as well: “Driving is not just an air pollution and […]

While I don’t find this surprising, it underscores the power of modern pharmacology. Many drugs deliver only incremental improvement, but semaglutide–like anti-hypertensives and statins–looks transformative for many people. “The diabetes and weight loss drug semaglutide significantly reduced symptoms and improved quality of life in people with obesity and the most common form of heart failure […]

Non-fungible tokens (NFTs) first came to my attention just a couple years ago. Apparently, anything could be an NFT. Per Investopedia: “Non-fungible tokens (NFTs) are assets that have been tokenized via a blockchain. They are assigned unique identification codes and metadata that distinguish them from other tokens. “NFTs can be traded and exchanged for money, […]

Now that COVID seems to be surging again, some timely reminders are in order: • keep your vaccination status current. The vaccine won’t keep you from being infected, but it will most likely keep you out of the ED and the morgue; • the outcome of COVID infection isn’t binary: death or survival. A third […]

According to this WaPo article, the average physician in the US earns $350K/yr. I didn’t click through to the actual data, but from the first table, I’m guessing that “average” means median, not mean. And physician income isn’t a Gaussian distribution—there’s a long right-hand tail for the specialties. Why is this? It looks to me […]

A recent discussion thread concerning the “lab leak” hypothesis for the origin of SARS-CoV-2 reminded me of another conspiracy theory involving claims of a bioweapon that also probably had a natural origin. The US government claimed that the Soviet Union was using trichothecene mycotoxins as biological weapons in Southeast Asia in the mid-1970s. In support […]