A clinical trial of hydroxychloroquine with 30 patients (15 treated 15 controls) has been completed in Shanghai. It is the first genuine randomized trial. It reports no evidence that hydroxychloroquine works at all. It is true, that given the principal outcome measure defined in advance, the trial has no power. Not low power, 0 power. […]
Chloroquine and Hydroxychloroquine are being tested as components of multi-drug cancer chemotherapy. I have noticed that when I tweet this, people conclude that I am insane. However this is not a tiny literature. \ Repurposing Drugs in Oncology (ReDO)—chloroquine and hydroxychloroquine as anti-cancer agents is a long review article and meta analysis. It cites seven […]
Patient privacy prevents precise calculation of the fraction of Covid 19 patients in the USA being treated with Hydroxychloroquine or Chloroquine. However, Hospitals are purchasing hugely increased amounts Christopher Rowland reports. Data gathered in the first 17 days of March by Premier Inc., a large group purchasing organization for 4,000 U.S. hospitals, showed a 300 […]
This is a comment on “Is Anthony Fauci Really Our Truthteller-in-Chief?” by Kevin Drum. I will briefly summarize. Drum quotes from the latest press conference “Is there any evidence to suggest that, as with malaria, it might be used as a prophylaxis against COVID-19? DR. FAUCI: No. The answer is no.” Later after Trump says […]
I will never forgive Donald Trump for saying something exceedingly controversial with which I agree. I hate to say this but I agree with Trump and disagree with Fauci on hydroxychloroquine and Remdesivir. Update: But don’t mix the Hydroxychloroquine with Azithromycin “Azithromycin: (Major) Avoid coadministration of hydroxychloroquine and azithromycin.” Thanks Ted Lieu I will discuss […]
Given the Coronavirus crisis, there will be bailouts. Should there be bailouts ? If so how should firms be bailed out ? I think it is useful to look at the last round of bailouts from 2008-9 for lessons learned. First with the benefit of hindsight, does it seem that bailing out firms was a […]
This is, in fact, another post on Coronavirus, but it will take me a while to get to the point. To put the conclusion here, I think that it is important to get the FDA out of the way (by executive order if necessary). The Food and Drug Act, as currently interpreted, requires the assumption […]
“First Case of 2019 Novel Coronavirus in the United States” Holshue et al 2020 I quote Treatment with intravenous remdesivir (a novel nucleotide analogue prodrug in development10,11) was initiated on the evening of day 7, and no adverse events were observed in association with the infusion. Vancomycin was discontinued on the evening of day 7, […]
The day before yesterday, the Fed made a somewhat unusual announcement of $500,000,000,000 of REPO offers a day for three days in a row. The idea was to let banks unload risky assets before they panicked nipping a financial crisis in the bud. This move was controversial. Unfortunately many critics act as if the Fed […]
I am in a city with a curfew (enforced ?) where only pharmacies, supermarkets and those stores where someone from China sells all sorts of household stuff are open. Rome hasn’t reached the dread levels of Wuhan and Milan, but the Italian government is trying to get ahead of the curve. It is strange and […]