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One Dose or Two?

One Dose or Two?

There are two theories out there about how to vaccinate.  One says, look, we have data only on the protocols that were adopted in the trials.  The Pfizer and Moderna vaccines were administered in two doses, three to four weeks apart.  We know that works.  Don’t mess with it.  Stick to the protocol and make sure everyone getting these vaccines gets both doses in the proper time frame.

The other says, our goal should be to get basic protection for as many people as possible as quickly as possible, especially since ominous variants are spreading.  We are in a race, and when time matters as much as it does now you cut a few corners.  Since it looks like vaccine effectiveness is pretty strong two weeks after the first dose, make sure we get that dose out there and then go back, when there’s time and enough supply, to top it up later.

As often with dichotomous choices, the best course is neither.