CDC numbers are much less than Johns Hopkins CSSE numbers. Their advice is good more or less, but their numbers are awful. They might have been valid when the page was last updated, but that was sometime yesterday.
A hitherto unknown cause of the Wuhan coronavirus outbreak [1–3] is reported here – a bacteria from the Prevotella genus. The number of Wuhan coronavirus deaths in mainland China has overtaken the SARS epidemic in the country. The high mortality is being caused by targeting only the virus (which is also present). This is a two pronged attack, as previously noted in ‘infection with human coronavirus NL63 enhances streptococcal adherence to epithelial cells‘ [6]. Prevotella is a well known pathogen, and can induce ‘Severe Bacteremic Pneumococcal Pneumonia in Mice with Upregulated Platelet-Activating Factor Receptor Expression’ [7].The RNA-seq data from Wuhan, China (PRJNA603194) has millions of reads of Prevotella proteins, and a few thousands from 2019-nCoV (Table 1). Similarly, the DNA sequences (PRJNA601630) of 6 patients from the same family in Hong Kong [3] shows significant presence of this bacteria. These sequences can be found at SI:China.RNA-seq/SampleSequences.fa(n=480K) and SI:HongKong/ALLsequences.fa(n=50k).Finally, the expression levels (Table 2) shows that the elongation factor Tu is the most expressed. ‘Elon- gation factor Tu (Tuf) is a new virulence factor of Streptococcus pneumoniae that binds human complement factors, aids in immune evasion and host tissue invasion’ [8].These are the only two studies I could find. Detection of the Prevotella in other samples will add more credence to this theory. Detection of the nCoV can be made very specific by looking for a 500bp in the spike protein [4], which would be a good candidate for vaccine development, protein-inhibition and diagnosis (which was non-specific for SARS in many cases, including the CDC test [5]). Anti-virals neeed to be supplemented with anti-bacterial agents to treat this disease.
Bert Schlitz
March 8, 2020 7:57 pm
Covid 19 is triggering a major disinflation
likbez
March 9, 2020 2:39 am
run75441,
Detection of the Prevotella in other samples will add more credence to this theory. Detection of the nCoV can be made very specific by looking for a 500bp in the spike protein [4], which would be a good candidate for vaccine development, protein-inhibition and diagnosis (which was non-specific for SARS in many cases, including the CDC test [5]). Anti-virals neeed to be supplemented with anti-bacterial agents to treat this disease.
This is a really new information. Thank you !
Pneumonia is the most common cause of severe cases of COVID-10 and it develops rather fast, sometimes on the fifth or seventh day.
run75441
March 9, 2020 8:40 am
likbez:
It is a combination virus + good old bug called strep. They have only been treating the virus so far.
Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies.
Gao J1, Tian Z2, Yang X2.
Author information
1Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao, China.2Department of Pharmacy, Qingdao Municipal Hospital, Qingdao, China.
Abstract
The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People’s Republic of China for treatment of COVID-19 infection in larger populations in the future.
CDC numbers are much less than Johns Hopkins CSSE numbers. Their advice is good more or less, but their numbers are awful. They might have been valid when the page was last updated, but that was sometime yesterday.
More Info:https://www.researchgate.net/publication/339008515_The_2019_Wuhan_outbreak_is_caused_by_the_bacteria_Prevotella_which_is_aided_by_the_coronavirus_possibly_to_adhere_to_epithelial_cells_-_Prevotella_is_present_in_huge_amounts_in_patients_from_both_Chin?fbclid=IwAR0ukN0qbtX7bS6LkTgOq2eFs-puoF3Y0-2qx9T0_BKFL5raCGvmHNaVa1g
A hitherto unknown cause of the Wuhan coronavirus outbreak [1–3] is reported here – a bacteria from the Prevotella genus. The number of Wuhan coronavirus deaths in mainland China has overtaken the SARS epidemic in the country. The high mortality is being caused by targeting only the virus (which is also present). This is a two pronged attack, as previously noted in ‘infection with human coronavirus NL63 enhances streptococcal adherence to epithelial cells‘ [6]. Prevotella is a well known pathogen, and can induce ‘Severe Bacteremic Pneumococcal Pneumonia in Mice with Upregulated Platelet-Activating Factor Receptor Expression’ [7].The RNA-seq data from Wuhan, China (PRJNA603194) has millions of reads of Prevotella proteins, and a few thousands from 2019-nCoV (Table 1). Similarly, the DNA sequences (PRJNA601630) of 6 patients from the same family in Hong Kong [3] shows significant presence of this bacteria. These sequences can be found at SI:China.RNA-seq/SampleSequences.fa(n=480K) and SI:HongKong/ALLsequences.fa(n=50k).Finally, the expression levels (Table 2) shows that the elongation factor Tu is the most expressed. ‘Elon- gation factor Tu (Tuf) is a new virulence factor of Streptococcus pneumoniae that binds human complement factors, aids in immune evasion and host tissue invasion’ [8].These are the only two studies I could find. Detection of the Prevotella in other samples will add more credence to this theory. Detection of the nCoV can be made very specific by looking for a 500bp in the spike protein [4], which would be a good candidate for vaccine development, protein-inhibition and diagnosis (which was non-specific for SARS in many cases, including the CDC test [5]). Anti-virals neeed to be supplemented with anti-bacterial agents to treat this disease.
Covid 19 is triggering a major disinflation
run75441,
This is a really new information. Thank you !
Pneumonia is the most common cause of severe cases of COVID-10 and it develops rather fast, sometimes on the fifth or seventh day.
likbez:
It is a combination virus + good old bug called strep. They have only been treating the virus so far.
That might also explain
https://www.ncbi.nlm.nih.gov/pubmed/32074550