CAR not crazy

Pulled up from a comment by Linda Eissenberg

the community has been exploring them [CAR crazy ideas] for some time.  For example, in the “Gene edited CAR-T” method section of this paper (Cooper, et al.  https://pmc.ncbi.nlm.nih.gov/articles/PMC6102094/), T cells were treated with IL2 and IL15 before putting the CAR gene into the T cells.  This work was moved into a clinical trial (Ghobadi, et al.  https://pubmed.ncbi.nlm.nih.gov/39149468/) and the remission rate (i.e., percentage of patients who no longer had detectable cancer) was 82% for the 13 patients for whom results were known when the trial was evaluated.  This work stands out for its creation of CAR-T cells that can be put into ANY patient (allogeneic T cells).  Heretofore only a patient’s own T cells (autologous T cells) could be used.