Relevant and even prescient commentary on news, politics and the economy.

Part ll on roles of government/private sector public health

Hat tip to Laura Wright at On Earth magazine and NRDC (National Resources Defense Council) for the following link:

CuraGen offers toxigenomic screens.

CuraGen’s industrialized Predictive Toxicogenomics Screen enables inexpensive cellular screening of thousands of compounds annually, and provides results on nine different modes of liver toxicity. Evidence of liver toxicity is one of the primary reasons that drug compounds fail during preclinical development. Nearly 75% of pharmaceutical research and development expenditures are devoted to developing drugs that never reach the market. Detailed information generated by this screen can be used by scientists to prioritize compounds based upon their potential for toxicity, in order to avoid work on compounds that are likely to fail in safety tests later in development.

CuraGen and Bayer scientists developed this unique assay by analyzing more than 100 known toxic compounds and identifying marker genes whose activity correlates with specific modes of liver toxicity. These genes have been subcategorized into
marker sets predictive of nine specific liver histopathologies, including cholestasis, necrosis, or hypertrophy, and have been affixed to gene expression microarrays for use in high-throughput comparative analysis. Drug compounds under review are applied in extremely small quantities to primary hepatocyte cells in vitro. The cellular activity of these dosed compounds is then evaluated against the proprietary toxicity markers. The results of this comparison provide scientists with a rank-ordered list of compounds based upon their potential for toxicity, which can be used in determining which compounds have the highest likelihood for successful clinical development.

CuraGen Corporation has been a pioneer in the field of pharmacogenomics, which includes the study of how drugs work, why drugs fail, and which characteristics are indicative of drug toxicity. CuraGen’s expertise stems from pharmacogenomic research conducted with many of the world’s leading pharmaceutical companies in prioritizing portions of their drug pipelines.

CuraGen Corporation (NASDAQ: CRGN) is a genomics-based pharmaceutical company.

More thoughts:

1) Is there a moral obligation of private companies to invest in public health as part of their own product development? If the current regulatory structure is not even knowledgeable about the issue as part of the public forum, is this wise?

2) In light of the US experience with Chinese products and safety, is it useful to wait for the EU regulations on cosmetics to take effect in the US instead of being more pro-active? Revlon and L’Oreal have volunteered to comply with EU rules and also sell the same to the US, but other companies have not, so known toxins remain in the market.

3) How do you see the balances of interests happening in the future?

More thoughts?

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Where is Balochistan?

Pakistani ISI and Iranian intelligence working together? And when you thought you knew the players.

Pakistani Intelligence ISI in collaboration with Iranian intelligence crafted a unique strategy to fight Baloch nationalists who are waging a deadly guerilla warfare against Pakistani Army in the Balochistan province – Islamize youth and kill Nationalists – according to sources in Balochistan . Baloch Nationalists have alerted Western Governments and think tanks abroad about this new development; witnessed by locals, widely circulated in baloch forums, that a promotional gathering of Tabligi was orchestrated under the watchful eyes of ISI on July 31 in Gawadar, the costal city Balochistan. One Mr.Archen Baloch said “Fanatic mullahism is been promoted proactively in collaboration with insignificant, discarded local mullahs against the Baloch nationalism which seeks the restoration of its national sovereignty over Balochistan. “. This phenomenon suggests that Pakistani intelligence is adding a new dimension to its Counter insurgence strategy to contain Baloch nationalists- who are regarded as secular, unlike other groups. IntelliBriefs sources in Pakistan say such events are “taking place in all over Balochistan, and this phenomenon suggest a new conspiracy against Baloch nationalist” and is also considered as “second force of Pakistani government after its armed force”.

While one need not be surprised about strong alliance between ISI and Islamic groups ,it is believed that ISI has activated its network of Mullahs to counter Baloch Nationalists after the failure of Pakistani army to crush the Baloch Resistance . Now Pakistan ” wants dilute the intensity of Baloch nationalism by mobilizing the religious elements in our society” said Archen Baloch . All these activities are funded by ISI and spearheaded by Mr.Mulana Sherani ,member of Pakistan national assembly and he heads JUI in Balochistan .

On Iranian side of Balochistan ,Abdolmalik Rigi’s open revolt against Iran has forced Iranians to use Mullahs as weapons against Baloch Nationalists . Iranian officials are spending sleepless nights over the unrest in its Sistan Balochistan Province which shares border with Pakistani side of Balochistan . Sources say Baloch are facing harassment by Iranian officials at the border who visit their relatives on the other side of the border in the Iran . They say “we have to go through harsh security by Pasdarane Inqalab, the Revolutionary Guard.” . IntelliBriefs learned that those who want to participate in religious gathering in Pakistani held Balochistan face no restrictions, they can pass the boarder without any document or “Rahdari” permit.

Map of tribal areas: The map did not translate, but is worth a look to see how porous all the borders are between political and tribal boundaries.

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The other side of the coin in Iraq

Reporters at the Institute for War and Peace Reporting offer insight into local political and military conditions in Basra. Reporting appears to dovetail with Cactus’s post.

The concrete walls that surround the Fadhila party’s compound in Sharish, north of Basra city centre, resemble the barricades around the fortified Green Zone in Baghdad. Last spring, fierce clashes erupted between Fadhila and the Mahdi Army, a paramilitary group loyal to radical Shia cleric Muqtada al-Sadr. Several people were killed on both sides and offices and buildings belonging to the two parties were destroyed. Mediators from tribes and other political parties managed to end the fighting but as Abu Ali al-Baaj, a mid-level Mahdi Army commander, put it, “The tensions were not buried for good.”

The reason for the battle was simple – as the governing party in Basra, Fadhila had replaced the head of the local electricity department, who happened to be a Sadr supporter. Behind the façade of democratic institutions such as councils and the police force, Iraq’s second-largest city with about 2.6 million inhabitants, has fallen into the grip of competing militias who are as suspicious of one another as rival mafia families. When the two militias began fighting over the post of electricity chief, the police force divided into factions which turned their weapons on one another. Police cars were used to transport militia members. The Fadhila party runs the provincial council of Basra and controls most of the government institutions there. It was founded after Saddam Hussein’s regime was toppled in April 2003, and holds 15 seats in the Iraqi parliament.

With leading Shia cleric Sheikh Mohammed al-Yaqubi as its spiritual leader, the party also features Basra’s governor Mohammed al-Waili among its leading members. Basra had so little to lose and so much to gain from the demise of Saddam Hussein’s regime that, initially at least, it had all of the makings of a post-liberation success story. The city had been neglected for at least a decade as punishment for its largely Shia population’s support for the 1991 rebellion against Ba’ath party rule.

Whichever party wins, residents fear they will be the losers. Many say all they want is decent public services and accountable officials.”The religious parties and coalitions plant fear and terror among people to make sure they keep their mouths shut,” said Ahmed al-Hassawi, a traffic policeman. “This creates a terrorised community that can’t hold officials accountable even when they make mistakes. “I don’t care about the name or approach of the party that runs the province – my concern is what they will provide for my children and me.”However, Basra could be set for another bout of turbulence well ahead of any election. After Maliki dismissed Governor Waili, the Fadhila party threatened to mount protests on July 30. The protests were called off at the last minute, apparently after the party received assurances that Waili’s replacement would again be drawn from its ranks rather than from some rival group.

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Absolute proof or preponderance of evidence?

This article in On Earth marks the beginning of research that might have far reaching consequences in how we view disease and how our consumption is currently involved in creating health problems:

Although some diseases are inherited through a single genetic mutation — cystic fibrosis and sickle cell anemia are examples — the classic “one gene, one disease” model doesn’t adequately explain the complex interplay between an individual’s unique genetic code and his or her personal history of environmental exposures. That fragile web of interactions, when pulled out of alignment, is probably what causes many chronic diseases: cancer, obesity, asthma, heart disease, autism, and Alzheimer’s, to name just a few. To unravel the underlying biological mechanisms of these seemingly intractable ailments requires that scientists understand the precise molecular dialogue that occurs between our genes and the environment — where we live and work, what we eat, drink, breathe, and put on our skin. Herbert’s literature scan was a nod in this direction, but actually teasing out the answers in a laboratory has been well beyond her or anyone else’s reach — until now.

The earliest prototype was devised about a decade ago; since then these tiny devices, as well as other molecular investigative tools, have grown exponentially in their sophistication, pushing medical science toward a new frontier.
Gene chips are small, often no larger than your typical domino or glass laboratory slide, yet they can hold many thousands of genes at a time. Human genes are synthesized and bound to the surface of the chip such that a single copy of each gene — up to every gene in an organism’s entire genome — is affixed in a grid pattern. The DNA microarray allows scientists to take a molecular snapshot of the activity of every gene in a cell at a given moment in time.

The process works this way: Every cell in your body contains the same DNA, but DNA activity — or expression — is different in a liver cell, say, than it is in a lung, brain, or immune cell. Suppose a scientist wishes to analyze the effect of a particular pesticide on gene activity in liver cells. (This makes sense, since it is the liver that processes and purges many toxins from the body.) A researcher would first expose a liver cell culture in a test tube to a precise dose of the chemical. A gene’s activity is observed through the action of its RNA, molecules that convey the chemical messages issued by DNA. RNA is extracted from the test tube, suspended in a solution, then poured over the gene chip. Any given RNA molecule will latch on only to the specific gene that generated it. The genes on the chip with the most RNA stuck to them are the ones that were most active in the liver cells, or most “highly expressed.” The genes that don’t have any RNA stuck to them are said to be “turned off” in those cells. Scientists use the micro array to compare the exposed cells to non-exposed, control cells (see sidebar). Those genes that show activity in the exposed cells but not in the control cells, or vice versa, are the ones that may have been most affected by the pesticide exposure.

…a scientist at the Natural Resources Defense Council (NRDC), who was then a postdoctoral researcher at the University of Maryland, designed an experiment that included the use of microarrays and other molecular tools to figure out how, exactly, mercury was interfering with both our nervous and immune systems. She grew cells in test tubes — one set for mouse brain cells, another for mouse liver cells — and exposed them to various doses of mercury so that she could see which genes were being switched on and off in the presence of the toxic metal. In the brain and the liver cells, she noticed unusual activity in the gene interleukin-6, which both responds to infection and directs the development of neurons.
“We thought we had mercury figured out,” says Ellen Silbergeld, a professor of environmental health sciences at Johns Hopkins University, who collaborated with Sass on the study. Genomic tools may identify effects of other chemicals by allowing scientists to “go fishing,” as Silbergeld puts it, for things they did not know to look for.

But first, a more fundamental question: Do we even understand what today’s chronic diseases are? It is beginning to appear that what we call autism may in fact be many illnesses that we’ve lumped together because those who are afflicted seem to behave similarly. Doctors base their diagnosis on behavioral symptoms, not on what caused those symptoms. Some scientists now refer to the condition as “autisms,” acknowledging that we’ve yet to find a single, unifying biological mechanism, despite the identification, in some studies, of a handful of genes that may confer increased vulnerability. But then, genes or environmental exposures that appear to be important causal factors in one study may not show up at all in another. This leaves scientists to wonder whether the problem isn’t that the disease is so diverse in its biological origins that only a truly massive study — involving many thousands of patients — would have the statistical power to tease apart the various factors involved.

Norway has a study going with 100,000 people on the impact of environment on disease symptoms and causes using this genetic array testing. Clinton started a program in 2000 looking at large numbers of Americans and possible causes of disease symptoms, and includes a number of data sets that could be used for more general purposes. Recruiting has not started to date due to funding problems. The UK is also beginning another large, long term study.

I have included mercury levels in unborns as an example of how innovation in diagnostic procedures will allow us to measure what I have called ‘subtle toxins’ in the environment not because effects are subtle, but measurement is. Our water contains lots of medications and soluble chemicals, and there are no procedures in place to determine safety to unborns and newborns, small children (under 5).

Our ignorance is not limited to dramatic breakthroughs in technological diagnostics, however. Some procedures are simply more commonsense. The American Academy of Pediatricians found that safety levels for mercury blood levels in pregnant women was determined by drawing blood from the mother. Later, it dawned on people to test blood levels from the cortical blood of the fetus, which turned out to average 70% higher levels of mercury than the mothers, and put the fetus way over limits of safety published by EPA. Mercury is fairly common in the environment.

This sort of research costs money, and if it goes where I think it will go over the next ten years, will create concern. Does this sort of research deserve funding by government? Is the initial funding something the current private sector would ever consider? Beginning results are not expected to be ready until 2011 or later, and final results from these particular studies could carry on for several decades.

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Charity begins at home

The NYT ran an article on charity:

CARE, one of the world’s biggest charities, is walking away from some $45 million a year in federal financing, saying American food aid is not only plagued with inefficiencies, but also may hurt some of the very poor people it aims to help.

In 2004, Mr. Maxwelhtt and Mr. Barrett made the case against the practice at CARE headquarters in Atlanta. They recalled that the senior vice president, Patrick Carey, who has since died, cautioned them that leaving the system would be like “an act of partial suicide” for the nonprofits. Nonetheless, CARE committed to the shift the following year. CARE says it will try to raise money to replace the lost revenues from philanthropies and other donors, and by making its own aid programs profitable.

One of those programs could be seen in action one recent afternoon in the Kenyan village of Poche. CARE has helped local women bypass local middlemen to sell pineapples at better prices in Nairobi’s big supermarkets, 10 hours away by road.

One woman, Doreen Amimo, a 52-year-old grandmother, has seen her weekly earnings rise to $18 from $11. She can now afford to feed and clothe an orphaned niece and nephew.
“And I never lack sugar in the house,” she said, “and we can have tea and milk every morning!”
These farmers are selling their fruit to a small company, Vegcare, that CARE and a Kenyan company started with an investment of $170,000 in 2005. Vegcare advises farmers on how to grow pineapples that meet supermarket standards, buys them and trucks them to a wholesaler in Nairobi that supplies Nakumatt, a Kenyan supermarket chain.

With the rules of the market in Africa, I had mostly thought that charities like ARC and the HEIFER PROJECT had a better idea for long run help for poorer countries. Innovation, hard work, and entrepreneur spirit for a worthy idea – the American ideal of the small farm and cooperative effort.

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Worries by income level

A Gallup Poll reveals a measure of concerns by income level:

What is the most important financial problem facing your family today (open ended)? I was unable to make the chart work. sorry.

by income

Under $30,000 % $30,000 -74,000 % $75,000 +%

Healthcare costs 22 Healthcare 20 Healthcare 12

Lack of money, 17 Energy prices 10 College costs 12
cash flow

Cost of home 8 Cost of home 9 Retirement 11
rent, own

Not enough money 8 Lack of money cash flow 9 Cost of home 9
to pay debts

Low wages 8

The figures have remained relatively stable over the course of the year.

This poll was done July 12-15. I wonder what this months and next may show.

Overall concern was taxes at 4%, interest rates at 1%.

1) College costs were not among the top for the middle group up to $74,000, or lower group.

2) Retirement was not in the running under $74,000.

3) Cost of the home was a concern in the over $75,000.
4) Cash flow was in the middle group but is not broken out. It would have been interesting to see it in thirds of this group.

Does anyone see other interesting concerns by income?

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Is China quietly moving away from US treasuries?

Aol money reports that China has reassured the US it is a firm holder of US treasuries.

China is a responsible investor in international financial markets, and our country’s foreign exchange reserves are managed with the operational goals of safety, liquidity and profit,” Xinhua quoted the central bank official as saying. The People’s Bank does not disclose the composition of the foreign exchange reserves, which have swelled in recent years as China’s exports surged and investors poured money into the country to profit from an economy now in its fourth straight year of double-digit growth. But the reserves have become a political issue both within China and between Beijing and Washington. As the dollar has fallen in value, the People’s Bank has come under pressure to diversify its holdings to maintain the value of the reserves and improve returns.

Aol money also reports:

China has scrapped rules that required local companies to convert a portion of their foreign earnings into Chinese currency, the government said Tuesday, in a move that could ease pressure on Beijing’s foreign exchange system. Companies now will be allowed to decide on their own how to use money earned abroad, the State Administration of Foreign Exchange said on its Web site. Previous rules requiring companies to convert at least 20 percent of foreign earnings into Chinese yuan boosted demand for the currency, increasing pressure for it to rise against the U.S. dollar and other foreign currencies.

The latest change could help to slow the growth of China’s $1.3 trillion foreign reserves accumulated by the central bank as it tries to curb pressure for prices to rise by draining money from the economy through bond sales. “This policy revision is an important reform in foreign exchange management,” the agency said on its Web site. “The implementation of the new policy will improve the autonomy and convenience of domestic companies, strengthen companies’ capital management and improve the international balance of payments.”

Until 2002, Chinese companies were required to bring home all the money they made abroad and obtain government permission to make new foreign investments. Beginning in 2002, companies were allowed to keep 20 percent of foreign revenues. That was raised to 50 percent in 2004 and 80 percent the following year.

Is this a quiet move to loosen reliance on US treasuries? What else does it accomplish?

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The Guardian has an article worth reading:

Lieutenant Clay Hanna looks sick and white. Like his colleagues he does not seem to sleep. Hanna says he catches up by napping on a cot between operations in the command centre, amid the noise of radio. He is up at 6am and tries to go to sleep by 2am or 3am. But there are operations to go on, planning to be done and after-action reports that need to be written. And war interposes its own deadly agenda that requires his attention and wakes him up.
When he emerges from his naps there is something old and paper-thin about his skin, something sketchy about his movements as the days go by.

The Americans he commands, like the other men at Sullivan – a combat outpost in Zafraniya, south east Baghdad – hit their cots when they get in from operations. But even when they wake up there is something tired and groggy about them. They are on duty for five days at a time and off for two days. When they get back to the forward operating base, they do their laundry and sleep and count the days until they will get home. It is an exhaustion that accumulates over the patrols and the rotations, over the multiple deployments, until it all joins up, wiping out any memory of leave or time at home. Until life is nothing but Iraq.

Hanna and his men are not alone in being tired most of the time. A whole army is exhausted and worn out. You see the young soldiers washed up like driftwood at Baghdad’s international airport, waiting to go on leave or returning to their units, sleeping on their body armour on floors and in the dust.

Where once the war in Iraq was defined in conversations with these men by untenable ideas – bringing democracy or defeating al-Qaeda – these days the war in Iraq is defined by different ways of expressing the idea of being weary. It is a theme that is endlessly reiterated as you travel around Iraq. ‘The army is worn out. We are just keeping people in theatre who are exhausted,’ says a soldier working for the US army public affairs office who is supposed to be telling me how well things have been going since the ‘surge’ in Baghdad began.

They are not supposed to talk like this. We are driving and another of the public affairs team adds bitterly: ‘We should just be allowed to tell the media what is happening here. Let them know that people are worn out. So that their families know back home. But it’s like we’ve become no more than numbers now.’

The first soldier starts in again. ‘My husband was injured here. He hit an improvised explosive device. He already had a spinal injury. The blast shook out the plates. He’s home now and has serious issues adapting. But I’m not allowed to go back home to see him. If I wanted to see him I’d have to take leave time (two weeks). And the army counts it.’

A week later, in the northern city of Mosul, an officer talks privately. ‘We’re plodding through this,’ he says after another patrol and another ambush in the city centre. ‘I don’t know how much more plodding we’ve got left in us.’

When the soldiers talk like this there is resignation. There is a corrosive anger, too, that bubbles out, like the words pouring unbidden from a chaplain’s assistant who has come to bless a patrol. ‘Why don’t you tell the truth? Why don’t you journalists write that this army is exhausted?’

But the exhaustion of the US army emerges most powerfully in the details of these soldiers’ frayed and worn-out lives. Everywhere you go you hear the same complaints: soldiers talk about divorces, or problems with the girlfriends that they don’t see, or about the children who have been born and who are growing up largely without them.

‘I counted it the other day,’ says a major whose partner is also a soldier. ‘We have been married for five years. We added up the days. Because of Iraq and Afghanistan we have been together for just seven months. Seven months … We are in a bad place. I don’t know whether this marriage can survive it.’

The anecdotal evidence on the ground confirms what others – prominent among them General Colin Powell, the former US Secretary of State – have been insisting for months now: that the US army is ‘about broken’. Only a third of the regular army’s brigades now qualify as combat-ready. Officers educated at the elite West Point academy are leaving at a rate not seen in 30 years, with the consequence that the US army has a shortfall of 3,000 commissioned officers – and the problem is expected to worsen.

And it is not only the soldiers that are worn out. The wars in Iraq and Afghanistan have led to the destruction, or wearing out, of 40 per cent of the US army’s equipment, totalling at a recent count $212bn (£105bn).

But it is in the soldiers themselves – and in the ordinary stories they tell – that the exhaustion of the US military is most obvious, coming amid warnings that soldiers serving multiple Iraq deployments, now amounting to several years, are 50 per cent more likely than those with one tour to suffer from acute combat stress.

I have said this is a different sort of war and was taking a much heavier toll on our troops than admitted by the powers that be. Fourth generation warfare demands re-thinking some of our priorities, especially by proponents of global conflict and defense who demand sacrifice. Especially before next April when desparation becomes the rule of the day.

Karl Rove gets to go home now to salvage his family from the long haul. And Mitt’s boys are hard at work in Iowa, keeping us safe from the Dems. My worry is for the citizens.

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Reader Dan and a Simple Shopping Survey

This is a first post for me as a member of Angry Bear contributors. I have several posts full of pretty charts, ground breaking medical news that I believe will impact health care and environmental issues together, and more of course on WTO GATS, but decided to keep this simple and everyday. Up to this point cactus has corrected my html errors with grace and patience, but now I am responsible for the look. Score one for ownership. This one has no html quirks.

Mrs. Dan and I had to shop for a new stove. We did have one with a glass top but it cracked a few years ago, and tops carry limited warranty anyway. We looked for one of the old-fashioned kind with electric coils, and discovered that no matter where we went, big or small stores carried only ONE stove that had electric coils out of extensive inventories of glass topped stoves. Our lonely choice was half to a third the price of comparable stoves, but did not have the automatic setting to 350 degree F. with the on switch, and had a couple manual knobs instead of digital mechanisms.

The price of the model we bought was the same at two stores who carried our choice, one a national chain and the other local. We bought at the national chain because installation was ‘free’ (true for us as immediate consumers), taking away the old stove was $10, as part of the sales tax free day in MA it was offered that day with a 15% sale price reduction plus 10% off as part of an advertised regular special, and then the common 5% savings from the uncollected state sales tax for that day. If this sounds like the Fed budget discussions, do not go there.
With the $190 savings Mrs. Dan bought a couch day bed for the office (which somehow cost more than $190, but I am a child of the 21st century, so it is to be expected). I was struck by the preponderance of gadgets at twice to three times the cost in the Gilded Age of kitchens. Granite counter tops are the rage.

Over the last two years, for $40,000, we had a new shingled roof (hired), renovated the laundry room, re-painted the downstairs walls in a striking bold color scheme, new kitchen floor (hired), re-finished old oak flooring, new forced water boiler, more insulation, and re-painted the outside of the house with new fascia boards and new screens for the porch. I have two sons and a daughter who spent time from far parts of the US to provide paid labor and expertise, but I am still able to paint 35′ up a peak.

It did not dawned on me that this accomplishment could be unique to a degree and old-fashioned. Hands on is quite valuable if you can try and creates value other than buying the work, and the money lost from ‘work’ as vacation (self-employed) for me is outweighed by the value of doing and connection. Adventure vacations are fun, but I think this marks many things for family values that no adventure vacation can touch.

Score one for ownership of work, family, and values. This old progressive is glad to join the fray.

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Credit

Credit Card debt bubbles through the financial world.

“Debt eventually leaks into other areas, whether it starts with the mortgage and goes to the credit card or vice versa,” said Cliff Tan, a visiting scholar at Stanford University and an expert on credit risk. “We’re starting to see leaks now.”
The value of credit card accounts at least 30 days late jumped 26 percent to $17.3 billion in October from a year earlier at 17 large credit card trusts examined by the AP. That represented more than 4 percent of the total outstanding principal balances owed to the trusts on credit cards that were issued by banks such as Bank of America and Capital One and for retailers like Home Depot and Wal-Mart.
At the same time, defaults _ when lenders essentially give up hope of ever being repaid and write off the debt _ rose 18 percent to almost $961 million in October, according to filings made by the trusts with the Securities and Exchange Commission.
Serious delinquencies also are up sharply: Some of the nation’s biggest lenders _ including Advanta, GE Money Bank and HSBC _ reported increases of 50 percent or more in the value of accounts that were at least 90 days delinquent when compared with the same period a year ago.
The AP analyzed data representing about 325 million individual accounts held in trusts that were created by credit card issuers in order to sell the debt to investors _ similar to how many banks packaged and sold subprime mortgage loans. Together, they represent about 45 percent of the $920 billion the Federal Reserve counts as credit card debt owed by Americans.

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